What Advances Are Being Made In DNA Sequencing

 Life Science Research-DNA Sequencing

DNA sequencing is the single greatest scientific breakthroughs to have occurred in the world of genetics.

Determining the order of nucleotides in a DNA sequence has opened up numerous doors in preventative health care.

Patients today can receive a personalized map of their genetics from online labs like 23AndMe.com that answers questions on hereditary conditions and predispositions to illness.

Recent advances in DNA testing mean that lives can potentially be saved if researchers catch these links and red flags quickly.

Improving The Sanger Method And Moving Forward With DNA Testing.

Life Science Research

The original method – Sanger sequencing – was revolutionary in its time. It provided answers and options where there had been none. However, modern genetics needs to evolve to meet requirements and expectations. The Sanger method, while beneficial, had become laborious and expensive. The time had come to speed up the process to make it more cost-effective and efficient. The first step was automation. This simply uses the same method through a faster autonomous system for a more efficient process.

The other of these recent advances in DNA testing is next-generation sequencing – often called next-gen for short. Next gen sequencing has some potential benefits. The first is the type of DNA that can now be a sequence. The process can now sequence all of an individual’s exons (protein-producing DNA). This whole exome sequencing will identify any potential problems with this vital area of DNA. Many disease-causing mutations or know to originate here, so there is a better chance of researcher looking in the right area.

Another benefit of this whole exome test is that it covers such a large amount of DNA. 1% of a person’s entire genome may not sound like much in the grand scheme of things, but it is a significant increase compare to older methods. Then there is the reduction time and money spent. A next-gen sequencing machine can sequence an individual’s whole genome in a few days, and some believe it will soon cost less than $1000 for users to get tested.

This whole exome sequence is a significant step forward for identifying the cause of illness and understanding an individual sequence. However, this focus on protein-producers only covers one part of the full sequence. There is no guarantee that the problems lie here. That is where whole genome sequencing comes in. This method looks at the precise order of every single nucleotide to spot variations and anomalies.

There Is Still Work To Be Perform To Make Sure That DNA Sequencing Is As Beneficial And Helpful As Possible.

Life Science Research

There are still indeterminate factors and limitations with the whole genome and whole exome sequencing. This applies in particular when incidental or secondary findings come into play. At the moment, these recent advances in DNA testing are still providing great opportunities. Researchers are now able to look at the causes of diseases and the structure of the human genome in new ways. New research into genetic variations can provide answers to health care issues, or only bring up new questions to answer. There are always new problems and considerations in genetic research. This ongoing development and research mean that we will continue to find faster, more efficient ways of answering them.


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